Daily Fish Oil Intake May Cut Heart Risks in Dialysis Patients
(ScienceDaily) — January 14, 2026: A major international clinical trial has found that daily fish oil supplements can significantly reduce serious cardiovascular risks in patients undergoing kidney dialysis, offering a rare breakthrough in kidney care.
Key Developments
- An international trial found daily fish oil supplements significantly reduced heart-related risks in dialysis patients.
- The PISCES study reported a 43% drop in serious cardiovascular events among participants taking fish oil.
- Researchers cautioned the findings apply only to dialysis patients, not the general population.
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According to the study, patients who took fish oil supplements experienced far fewer heart attacks, strokes, and cardiac-related deaths compared to those who received a placebo. Researchers said the findings are especially important as dialysis patients face extremely high cardiovascular risk and have limited proven treatment options.
The research, known as the PISCES trial, was co-led in Australia by Monash Health and the School of Clinical Sciences at Monash University. It followed 1,228 dialysis patients across 26 medical sites in Australia and Canada.
The results were presented at the American Society of Nephrology Kidney Week 2025 and simultaneously published in The New England Journal of Medicine.
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Participants who consumed four grams of fish oil daily—containing omega-3 fatty acids EPA and DHA—showed a 43 percent reduction in serious cardiovascular events. These outcomes included heart attacks, strokes, cardiac-related deaths, and vascular-related amputations.
Adjunct Professor Kevan Polkinghorne, a nephrologist at Monash Health and one of the lead investigators, described the results as highly significant.
“Patients on dialysis have extremely high cardiovascular risk, and very few therapies have been shown to reduce that risk. In a field where many trials have been negative, this is an important finding,” he said.
Researchers noted that dialysis patients typically have much lower levels of EPA and DHA than the general population, which may explain the strong protective effect observed in the trial.
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However, Professor Polkinghorne stressed that the findings apply only to people receiving hemodialysis for kidney failure and should not be extended to healthy individuals or other patient groups without further research.
The Australian arm of the study was funded by the National Health and Medical Research Council (NHMRC), while overall trial coordination was handled by the Australasian Kidney Trials Network (AKTN). International leadership came from Professor Charmaine Lok and her team at the University Health Network in Toronto and the University of Calgary.
While fish oil is widely known for broader health benefits, including brain, skin, and bone health, researchers emphasized that its proven cardiovascular impact in this study is specific to dialysis patients, marking a significant step forward in managing heart risks among those with kidney failure.
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